Vasculitis & polymyalgia rheumatica
Distinct predictors of peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitis: KEIO-vasculitis cohort
Authors' conclusion
Baseline eosinophil counts may be useful predictors for both the presence and motor involvement of peripheral neuropathy in patients with EGPA, highlighting their clinical utility and early risk stratification.
Study context
- Population
- Consecutive patients with newly diagnosed, treatment-naïve, active AAV (KEIO-vasculitis cohort)
- Participants
- 111 patients
- Exposure
- No peripheral neuropathy vs sensory neuropathy vs sensorimotor neuropathy
- Outcome
- Baseline factors associated with peripheral neuropathy in AAV
- Follow-up
- Baseline
Methodological detailsconsecutive patients, stratified by disease subtype
- Consecutive patients
- Stratified by disease subtype
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Baseline eosinophil counts by peripheral neuropathy severity (EGPA subgroup) — Without peripheral neuropathy vs Sensory neuropathy and Sensorimotor neuropathy · stepwise increase with severity
P = 0.004
Eosinophil count cutoffs to predict peripheral neuropathy and sensorimotor neuropathy (EGPA subgroup) · baseline
- Cutoff for peripheral neuropathy 2468/μL: sensitivity 90 %, specificity 75 %
- Cutoff for sensorimotor neuropathy 6724/μL: sensitivity 80 %, specificity 71 %
Neutrophil-to-lymphocyte ratio by peripheral neuropathy severity (GPA and MPA subgroup) · baseline
- Tended to rise with increasing severity, not statistically significant
Original publication
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