Vasculitis & polymyalgia rheumatica
Elevated levels of serum angiopoietin-1, IL-17, osteopontin and CXCL-9 as markers of vascular inflammation in newly diagnosed PMR
Authors' conclusion
sGCA in PMR has a biomarker signature that more closely resembles GCA than PMR. Baseline levels of angiopoietin-1, IL-17, osteopontin and CXCL-9 may help identify PMR patients with vascular inflammation.
Study context
- Population
- Consecutive new patients with PMR or GCA, Tallaght University Hospital and St James Hospital, Dublin
- Participants
- 53 / 13 / 59
- Comparison
- Serum biomarkers in PMR with subclinical GCA vs pure PMR
- PMRn = 53reference
- sGCAn = 13
- GCAn = 59
- Outcome
- Diagnostic value of serum angiopoietin-1, angiopoietin-2, IL-6, IL-17A, IL-23, CXCL-9 and osteopontin in identifying vascular inflammation in PMR
- Follow-up
- Baseline
Methodological detailsmulticentre, consecutive new patients, standardized vascular ultrasound (US) of bilateral temporal and axillary arteries
- Multicentre
- Consecutive new patients
- Standardized vascular US of bilateral temporal and axillary arteries
Performance
As reported in the abstract
Serum biomarkers, sGCA in PMR vs pure PMR, and diagnostic performance (ROC)
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| Angiopoietin-1 | 0.801 | 84.6 | 70% |
| IL-17 | 0.892 | 84.6% | 79.2 |
| Osteopontin | 0.814 | 84.5% | 79.2% |
| CXCL-9 | 0.892 | 92.3% | 62.3% |
AUC
Angiopoietin-10.801
IL-170.892
Osteopontin0.814
CXCL-90.892
Sensitivity
Angiopoietin-184.6
IL-1784.6%
Osteopontin84.5%
CXCL-992.3%
Specificity
Angiopoietin-170%
IL-1779.2
Osteopontin79.2%
CXCL-962.3%
- sGCA vs PMR: P < 0.001
- sGCA vs PMR: P = 0.004
Further findings
| Outcome | P value |
|---|---|
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P < 0.001 |
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P < 0.001 |
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P < 0.001 |
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P < 0.001 |
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P = 0.02 |
| Serum biomarkers, GCA vs PMR (higher levels in GCA)GCA vs PMR | P < 0.001 |
Original publication
Elevated levels of serum angiopoietin-1, IL-17, osteopontin and CXCL-9 as markers of vascular inflammation in newly diagnosed PMR. Rheumatology (Oxford). Published 12 November 2025. doi:10.
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