Vasculitis & polymyalgia rheumatica
Integrated bulk and single-cell transcriptomics identifies shared and specific immune signatures in Takayasu Arteritis
Authors' conclusion
Integrated bulk and single-cell transcriptomics reveal both shared and subset-specific signaling landscapes for CD4⁺ and CD8⁺ T cells in TAK.
Study context
- Population
- Treatment-naïve patients with TAK; healthy and atherosclerotic controls
- Participants
- 8 / 3 / 3 / 3
- Comparison
- Treatment-naïve TAK vs age-matched healthy controls (blood) and atherosclerotic controls (aortic tissue)
- TAK (blood)n = 8
- Healthy controlsn = 3reference
- TAK (aorta)n = 3
- Atherosclerotic controlsn = 3reference
- Outcome
- DEGs (false-discovery rate < 0.05) and immune signatures
Methodological detailsbulk RNA-sequencing of peripheral-blood CD4⁺ and CD8⁺ T cells, single-cell RNA-sequencing of aortic tissue
- Bulk RNA-sequencing of peripheral-blood CD4⁺ and CD8⁺ T cells
- Single-cell RNA-sequencing of aortic tissue
Main finding
As reported in the abstract
DEGs in CD4⁺ T cells (bulk)
851
DEGs in CD8⁺ T cells (bulk)
1 645
Original publication
Integrated bulk and single-cell transcriptomics identifies shared and specific immune signatures in Takayasu Arteritis. Arthritis Res Ther. Published 11 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →