Vasculitis & polymyalgia rheumatica
Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis
Authors' conclusion
The findings underscore the active involvement of various immune and structural cells in the aortic tissues of TAK patients and reveal the presence of the complement signaling pathway in peripheral blood T cells.
Study context
- Population
- TAK patients and matched healthy volunteers, Anzhen Hospital, Capital Medical University, China, January 2020–December 2023
- Comparison
- TAK patients vs controls (public database) for aortic tissue; TAK patients vs matched healthy volunteers for peripheral T cells
- TAKn = 3
- TAK (peripheral T cells)n = 8
- Healthy volunteersn = 8reference
Methodological detailssingle-cell transcriptome analysis, bulk RNA sequencing, single-centre
- Single-cell transcriptome analysis
- Bulk RNA sequencing
- Single-centre
Main finding
As reported in the abstract
- 11 predominant cell types identified in aortic tissues, with notable differences in proportions between TAK patients and controls
- T cells, B cells, macrophages, smooth muscle cells (SMCs) and fibroblasts showed subtype-specific gene expression signatures, with notable changes in interactions between T cells, B cells and monocyte-macrophages
- Upregulation of complement system genes in peripheral blood T cells from TAK patients
Original publication
Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis. Arthritis Res Ther. Published 10 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →