Vasculitis & polymyalgia rheumatica
Rheumatoid factor positivity in granulomatosis with polyangiitis: implications for clinical outcomes and immunological profiles
Authors' conclusion
Rf positivity in GPA is associated with distinct clinical and immunological profiles, including an arthritis-dominant phenotype and reduced skin involvement.
Study context
- Population
- Patients with Granulomatosis with Polyangiitis (GPA), single-centre cohort
- Participants
- 82 patients
- Exposure
- Rheumatoid factor (Rf)-positive vs Rf-negative GPA
- Rf +n = 37
- Rf -n = 45reference
- Outcome
- Clinical, laboratory and immunological profile by Rf status
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Significantly higher c-ANCA, total protein-to-albumin ratio, WBC count, neutrophil-to-lymphocyte ratio and Birmingham Vasculitis Activity Score (BVAS) in Rf + patients
- Arthritis significantly more prevalent in Rf + patients
- Skin involvement inversely associated with Rf positivity
- Lower end-stage renal disease (ESRD) prevalence in Rf + patients despite similar overall disease durations, potentially related to higher RTX usage
Observational data: associations, not effects.
Original publication
Rheumatoid factor positivity in granulomatosis with polyangiitis: implications for clinical outcomes and immunological profiles. Clin Exp Rheumatol. Published 6 March 2025. doi:10.
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