Vasculitis & polymyalgia rheumatica
Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis
Authors' conclusion
The FRS can be used at diagnosis to assess the relapse risk in patients with GPA or MPA.
Study context
- Population
- Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients from five consecutive RCTs (long-term follow-up); validated in an independent GPA/MPA cohort203 GPA, 224 MPA
- Participants
- 427 participants
- Comparison
- FRS 0 vs 1 vs 2 vs 3 points
- Outcome
- Relapse (death as competing event)
Methodological detailspooled data from five randomised controlled trials, competing-risks model, independent validation cohort
- Pooled data from five randomised controlled trials
- Competing-risks model
- Independent validation cohort
Performance
As reported in the abstract
Variables at diagnosis associated with relapse risk
PR3 positivity, HR (95% CI 1.28 to 2.57); p<0.001
1.81
Age ≤75 years, HR (95% CI 1.15 to 3.13); p=0.012
1.89
Estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m², HR (95% CI 1.18 to 2.33); p=0.004
1.67
Patients with ≥1 relapse (48.5%), mean±SD follow-up 80.6±51.3 months
207
Further findings
5-year relapse risk by FRS, validation cohort (n=209)
Original publication
Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis. RMD Open. Published 27 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →