Vasculitis & polymyalgia rheumatica
Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis
Authors' conclusion
A specific increase in oral-derived Campylobacter in the gut may be a novel predictor of aortic aneurysm formation/progression in patients with TAK.
Study context
- Population
- Patients with TAK and healthy controls
- Participants
- 76 vs 56
- Exposure
- Patients with TAK vs healthy controls
- TAKn = 76
- Healthy controls (HCs)n = 56reference
- Outcome
- Gut dysbiosis in TAK and specific gut microorganisms related to aortic aneurysm formation/progression
Methodological details16S ribosomal RNA sequencing of faecal microbiome
- 16S ribosomal RNA sequencing of faecal microbiome
Main finding
As reported in the abstract
Gut microbiota composition
- TAK showed altered gut microbiota with higher abundance of oral-derived bacteria (e.g. Streptococcus, Campylobacter) than HCs, regardless of disease activity
- Increase significantly associated with proton pump inhibitor administration
- Among patients taking a proton pump inhibitor, Campylobacter more frequently detected in those who underwent vascular surgeries and endovascular therapy for aortic dilatation
- Campylobacter gracilis significantly associated with clinical events related to aortic aneurysm formation/worsening
Observational data: associations, not effects.
Further findings
Interventions for aortic dilatation (prospective analysis)
- Campylobacter-positive patients significantly more likely to require interventions for aortic dilatation than Campylobacter-negative
Severe aortic aneurysm by C. gracilis PCR
- C. gracilis PCR-positive patients showed a tendency to have severe aortic aneurysms
Original publication
Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis. Arthritis Res Ther. Published 24 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →