Vasculitis & polymyalgia rheumatica
Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study
Main finding · Severe infectionResult — go to the resultConfounder-adjusted HR 1.75 95% CI 1.03–3.00Authors' conclusion
Regardless of treatment regimens, low IgG after remission-induction treatment was associated with the development of severe infections up to 48 weeks after treatment initiation.
Study context
- Population
- Patients with new-onset or severe relapsing antibody-associated vasculitis (AAV) in the J-CANVAS registry, 24 referral sites in JapanIgG measured in 510
- Participants
- 657 patients
- Exposure
- Low IgG vs higher IgG during remission-induction therapy
- Low IgGn = 77
- Outcome
- Severe infection
- Follow-up
- Up to 48 weeks after treatment initiation
Methodological detailsmulticentre (24 referral sites, J-CANVAS registry), multiple imputation, Fine-Gray model, restricted cubic spline
- Multicentre (24 referral sites, J-CANVAS registry)
- Multiple imputation
- Fine-Gray model
- Restricted cubic spline
Main finding
As reported in the abstract
up to 48 weeks
Confounder-adjusted HR
1.75
95% CI 1.03–3.00
Low IgGvs IgG ≥500 mg/dl
confounder-adjusted HR 1.75 (95% CI 1.03–3.00)
Observational data: associations, not effects.
Further findings
Severe infection, whole cohort · up to 48 weeks
- Patients developing severe infections
- 111 (16.9%)
Low IgG prevalence among patients with IgG measured · up to 24 weeks
- Low IgG
- 77 (15.1%)
Serum IgG and severe infection (restricted cubic spline (RCS))
- U-shaped association; lowest point at serum IgG (mg/dl)
- 946
Treatment-regimen subgroups
- No obvious heterogeneity between treatment regimens
Original publication
Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study. Rheumatology (Oxford). Published 24 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →