Vasculitis & polymyalgia rheumatica
Phenotypic clusters of patients with Takayasu arteritis predict disease activity at presentation, damage and future vascular complications
Authors' conclusion
Phenotypic clusters of TAK reflected distinct angiographic involvement with prognostic implications.
Study context
- Population
- Patients with TAK from three cohorts from India and Türkiye
- Participants
- 564 patients3 cohorts
- Comparison
- Phenotypic clusters 2A and 2B vs cluster 1
- Outcome
- Clinical outcomes in cluster 2A vs cluster 1
Methodological detailsagglomerative hierarchical clustering, three cohorts from India and Türkiye, Cox regression
- Agglomerative hierarchical clustering
- Three cohorts from India and Türkiye
- Cox regression
Main finding
As reported in the abstract
Each group vs cluster 1Estimate (95% CI)
Cluster 2A
aOR (initiation of GC) 0.51(0.31–0.83)
Cluster 2A
aOR (initiation of immunosuppressants) 0.35(0.20–0.60)
Cluster 2A
aOR (new-onset vascular complications) 0.22(0.07–0.74)
Further findings
| Outcome | HR for death (95% CI) | |
|---|---|---|
| Survival (mortality, Cox regression)Cluster 2Avs Cluster 1 | 0.99 (0.43–2.29) | |
| Survival (mortality, Cox regression)Cluster 2Bvs Cluster 1 | 1.20 (0.84–1.70) | |
| 0.512HR for death (log scale) |
Survival (mortality, Cox regression)
- Survival was similar across clusters
Original publication
Phenotypic clusters of patients with Takayasu arteritis predict disease activity at presentation, damage and future vascular complications. Rheumatology (Oxford). Published 20 September 2025. doi:10.
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