Vasculitis & polymyalgia rheumatica
Comparison of clinical features between patients with young-onset and late-onset Takayasu's arteritis
Authors' conclusion
Results of this study revealed that patients with LOTAK exhibited higher frequencies of vascular bruit, reduced brachial arterial pulse, and systolic blood pressure differences in arms, but a lower frequency of ascending aorta involvement than those with YOTAK.
Study context
- Population
- Patients with TAK per the 2022 ACR/EULAR classification criteria (median age 45.0 years; 89.1% female)
- Participants
- 138 patients
- Exposure
- Late-onset TAK vs young-onset TAK
- Young-onset TAK (YOTAK)n = 47reference
- Lateonset TAK (LOTAK)n = 91
- Outcome
- Frequencies of items satisfied in the 2022 ACR/EULAR classification criteria for TAK
Methodological detailsmedical records review
- Medical records review
Main finding
As reported in the abstract
Frequencies of 2022 criteria items
LOTAK vs YOTAKOdds ratio (95% CI)P value
Vascular bruit: 85.7% vs. 70.2%
2.55(1.08–6.00)
P = 0.030Reduced pulse in upper extremities: 73.6% vs. 42.6%
3.77(1.79–7.92)
P < 0.001Systolic BP difference in arms: 96.7% vs. 87.2%
4.29(1.02–18.02)
P = 0.033Ascending aorta involvement: 7.7% vs 19.1%
0.35(0.12–0.99)
P = 0.046Observational data: associations, not effects.
Original publication
Comparison of clinical features between patients with young-onset and late-onset Takayasu's arteritis. Clin Exp Rheumatol. Published 17 September 2025. doi:10.
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