Vasculitis & polymyalgia rheumatica
Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis
Authors' conclusion
Gene signatures of monocyte activation and B cell inactivation were characteristic of GCA and associated with treatment response.
Study context
- Population
- Treatment-naive patients with giant cell arteritis (GCA), patients with TAK, and old and young healthy controls
- Comparison
- Treatment-naive GCA vs TAK, age-matched old healthy controls (HCs) and young HCs
- Outcome
- Characteristic genes for GCA and their longitudinal transition (CIBERSORT)
Methodological detailslongitudinal, whole blood transcriptome analysis, CIBERSORT
- Longitudinal
- Whole blood transcriptome analysis
- CIBERSORT
Main finding
As reported in the abstract
Gene signatures characteristic of GCA
Differentially expressed genes among all patients and HCs (repeated measures ANOVA)
739
Genes characteristically upregulated in GCA vs TAK and HCs
15
Genes characteristically downregulated in GCA vs TAK and HCs
36
Further findings
Longitudinal transition under treatment · 6 weeks
- Monocyte activation toward M0-like phenotypes persisted under 6 weeks of treatment
- Prednisolone plus IL-6R antagonist normalized molecular profiles more efficiently than prednisolone monotherapy
Original publication
Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis. Arthritis Res Ther. Published 3 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →