Vasculitis & polymyalgia rheumatica
Maternal–fetal outcomes and therapeutic strategies in pregnancies complicated by Takayasu arteritis: a comprehensive analysis
Authors' conclusion
TA significantly elevates maternal-fetal risks, driving hypertension, growth restriction, and preterm birth via vasculopathic-inflammatory pathways.
Study context
- Population
- Pregnancies complicated by TAK: West China Second Hospital (2012–2024) and 16 studies globally17 patients
- Participants
- 20 pregnancies
- Outcome
- Maternal-fetal outcomes and therapeutic efficacy in TAK-complicated pregnancies
Methodological detailsdual-design, single-centre retrospective analysis, random-effects meta-analysis, meta-regression
- Dual-design
- Single-centre retrospective analysis
- Random-effects meta-analysis
- Meta-regression
Pooled result
As reported in the abstract
Maternal-fetal outcomes
- Cohort: ≥1 obstetric complication
- 50%
- Cohort: arterial stenosis
- 80%
- Cohort: hypertension
- 40%
- Meta-analysis: adverse outcomes
- 42.6%
- Meta-analysis: gestational hypertension
- 26.1%
- Meta-analysis: fetal growth restriction
- 17.7%
- Meta-analysis: preterm delivery
- 13.6%
Further pooled results
Inflammatory indicators and pregnancy outcomes
| OR (95% CI) | ||
|---|---|---|
| CRP (prepartum)No statistically significant association | 1.001 (0.969–1.034) | |
| CRP (postpartum)No statistically significant association | 1.058 (0.920–1.217) | |
| ESRNo statistically significant association | 1.024 (0.952–1.101) | |
| 0.512Odds ratio (log scale) |
Laboratory metrics vs normative standards (n = 20)
- Elevated WBC, PCT, TT, fibrinogen, urinary protein and ALT
- all P < 0.05
- Reduced PT, albumin and bilirubin
- P < 0.05
GC (prednisone vs methylprednisolone) or immunosuppressants, pre-pregnancy or gestational, and complications
- No significant reduction in complications (all RR 95% CI crossed 1)
- P > 0.05
Antihypertensive therapy and preeclampsia
- No correlation
- P > 0.05
Original publication
Maternal–fetal outcomes and therapeutic strategies in pregnancies complicated by Takayasu arteritis: a comprehensive analysis. Arthritis Res Ther. Published 4 December 2025. doi:10.
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