Vasculitis & polymyalgia rheumatica

Recommendations of the German, Austrian and Swiss rheumatology and other medical societies for the management of polymyalgia rheumatica

Rheumatology (Oxford)Published Guideline

Methodological detailsupdated recommendations, systematic literature search, task force consensus, Systematic literature search of evidence published July 2016–January 2024 on therapeutic interventions and prognostic factors for polymyalgia rheumatica (PMR), Task force of 12 physicians, two healthcare professionals and two patients from three countries; four overarching principles and seven specific recommendations
  • Updated recommendations
  • Systematic literature search
  • Task force consensus
  • Systematic literature search of evidence published July 2016–January 2024 on therapeutic interventions and prognostic factors for PMR
  • Task force of 12 physicians, two healthcare professionals and two patients from three countries; four overarching principles and seven specific recommendations

Recommendations

As issued by the authors

  1. GC (15-25 mg prednisone equivalents per day) as initial treatment for PMR once diagnosis confirmed, with subsequent tapering over 4-12 months (depending on whether a GC sparing agent is used), with monitoring of disease activity and treatment-related adverse effects

  2. IL-6R blocking agents should be considered in addition to GC in patients with relapsing disease and can be considered in new-onset PMR at high risk for GC-related adverse events

  3. MTX or RTX may be alternatives

  4. Older and frail patients should also be offered an individualized exercise program

Original publication

Recommendations of the German, Austrian and Swiss rheumatology and other medical societies for the management of polymyalgia rheumatica. Rheumatology (Oxford). Published 4 December 2025. doi:10.1093/rheumatology/keaf646

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