Vasculitis & polymyalgia rheumatica
The impact of demographics on organ damage in Behçet’s syndrome: a cross-sectional analysis of the international PROBE cohort
An erratum to this article was published (Rheumatology (Oxford), 5 Mar 2026 ↗)
Authors' conclusion
This study demonstrates how the extent, prevalence and characteristics of damage in BS vary with demographic factors, underscoring their importance in research and personalized management.
Study context
- Population
- Patients with Behçet's syndrome, international multiethnic PROBE cohort
- Participants
- 970 patients
- Exposure
- Demographic factors and organ damage
- Outcome
- Extent and prevalence of organ damage measured by the Behçet's syndrome (BS) Overall Damage Index (BODI)
Methodological detailsancillary analysis of the PROBE project, multiethnic cohort, multivariate linear and logistic regression
- Ancillary analysis of the PROBE project
- Multiethnic cohort
- Multivariate linear and logistic regression
Main finding
As reported in the abstract
Damage (BODI) by demographics
- Median BS Overall Damage Index (BODI) score (IQR)
- 1 (0-3)
- Patients with BODI ≥1
- 65.6%
- Males: higher damage, β
- 0.103
- Males: total damage prevalence, adjOR (per 10 years)
- 1.7
- Males: ocular damage, adjOR
- 1.6
- Males: vascular damage, adjOR
- 2.1
- Age: greater damage, β
- 0.104
- Age: overall damage, adjOR
- 1.4
- Age: neuropsychiatric damage, adjOR
- 1.2
- Age: miscellaneous damage, adjOR
- 2.0
- Low education: overall damage, adjOR
- 1.9
- Low education: ocular damage, adjOR
- 1.6
- North African vs South European: greater damage, β
- 0.400
- North African vs Middle Eastern: greater damage, β
- 0.314
- North African vs South European: overall damage, adjOR
- 13.9
- North African vs Middle Eastern: overall damage, adjOR
- 10.7
Observational data: associations, not effects.
Original publication
The impact of demographics on organ damage in Behçet’s syndrome: a cross-sectional analysis of the international PROBE cohort. Rheumatology (Oxford). Published 29 November 2025. doi:10.
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