Vasculitis & polymyalgia rheumatica
Assessment of long-term organ damage and predictors of damage accrual in Behçet's syndrome: a 10-year longitudinal study using the Behçet's Syndrome Overall Damage Index
Authors' conclusion
Organ damage in BS is associated with different factors depending on the disease stage: while demographic features, particularly non-Italian origin and older age, significantly predict the presence of damage at diagnosis, older age and corticosteroid therapy are associated with damage accrual in the long-term.
Study context
- Population
- Behçet's syndrome (BS) patients followed for at least six months, real-life cohort
- Participants
- 155 patients
- Outcome
- Organ damage (BODI score ≥1) and damage accrual (ΔBODI ≥1 between timepoints)
- Follow-up
- 10-year follow-up
Methodological detailssingle-centre, longitudinal, multivariable logistic regression
- Single-centre
- Longitudinal
- Multivariable logistic regression
Main finding
As reported in the abstract
Damage at diagnosis
31.1%
Damage at 10-year follow-up
53.8%
Damage accrual by 10-year follow-up
39.7%
Observational data: associations, not effects.
Further findings
Predictors of damage at baseline and of damage accrual (multivariable analysis)
- Pre-existing damage at diagnosis was a risk factor for faster accumulation of new damage
- Non-Italian origin and older age at diagnosis independent predictors of damage at baseline
- Older age remained a significant predictor of damage accrual during 10-year follow-up
- Accumulation of new damage associated with more frequent GC treatment
Original publication
Assessment of long-term organ damage and predictors of damage accrual in Behçet's syndrome: a 10-year longitudinal study using the Behçet's Syndrome Overall Damage Index. Clin Exp Rheumatol. Published 27 February 2026. doi:10.
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