Vasculitis & polymyalgia rheumatica
Clinical outcomes of subglottic stenosis in granulomatosis with polyangiitis: results of an international multicentre observational study
Main finding · SGS relapse by treatmentResult — go to the resultHazard ratio 0.33Authors' conclusion
Systemic immunosuppressive therapy, particularly CYC-based induction, was associated with fewer SGS relapses and prolonged relapse-free survival, while glucocorticoid monotherapy was less effective.
Study context
- Population
- Granulomatosis with polyangiitis (GPA) patients with subglottic stenosis (SGS)30% male
- Participants
- 89 patients
- Exposure
- Higher relapsers (≥2 flares) vs lower relapsers (≤1 flare); treatment regimens compared for relapse
- Higher relapsersn = 48
- Outcome
- Relapse of SGS (predictors of relapse and multiple flares; time-to-relapse across regimens)
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
SGS relapse by treatment
Hazard ratio
0.33
P = 0.049
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Higher relapsers and time-to-relapse
- 54% · 48
- Higher relapsers and time-to-relapse — Median time-to-relapse
- 36 months
Original publication
Clinical outcomes of subglottic stenosis in granulomatosis with polyangiitis: results of an international multicentre observational study. Rheumatology (Oxford). Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →