Vasculitis & polymyalgia rheumatica
Concordance between presenting features and relapse in granulomatosis with polyangiitis: implications for risk assessment and counselling
Authors' conclusion
Although new features can still emerge, organ involvement at diagnosis is associated with a higher likelihood of relapse in the same organ.
Study context
- Population
- Newly diagnosed patients with GPA in a national databasemedian follow-up 3.5 years
- Participants
- 795 participants
- Exposure
- Organ involvement at diagnosis vs organ involvement at first relapse
- Outcome
- Concordance between organ involvement at diagnosis and at relapse
Methodological detailsnational database of newly diagnosed patients, multivariable logistic regression
- National database of newly diagnosed patients
- Multivariable logistic regression
Main finding
As reported in the abstract
Relapse in the same organ, by organ involvement at diagnosis
- Eyes, OR
- 6.69
- Lungs, OR
- 3.35
- Kidneys, OR
- 3.58
- Nervous system, OR
- 2.90
- Mucocutaneous, OR
- 4.53
- First relapse affected only the initially involved organs
- 56%
Observational data: associations, not effects.
Further findings
Relapse · median follow-up 3.5 years
- Patients who relapsed
- 394 (50%)
- Organ involvement at relapse available
- 376
New organ manifestations at relapse
- Patients with new organ manifestations
- 165
- Isolated new manifestations
- 34
- Alongside at least one previously affected organ
- 131
- Systemic, ear, nose and throat (ENT) and lung manifestations at diagnosis associated with lower risk of new organ disease at relapse (multivariable analysis)
Major manifestations associated with higher likelihood of recurrence
- Scleritis, pachymeningitis, subglottic stenosis and worsening renal function
Original publication
Concordance between presenting features and relapse in granulomatosis with polyangiitis: implications for risk assessment and counselling. RMD Open. Published 31 December 2025. doi:10.
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