Vasculitis & polymyalgia rheumatica
M-CSF, inducing CD163 macrophages, is associated with severity and prognosis of glomerulonephritis in microscopic polyangiitis
Authors' conclusion
The serum M-CSF level may serve as a biomarker that reflects RPGN severity and predicts progression to ESRD in patients with MPA.
Study context
- Population
- Patients with microscopic polyangiitis (MPA)5 kidney biopsy specimens
- Participants
- 73 patients
- Comparison
- MPA with rapid progressive glomerulonephritis (RPGN) vs MPA without RPGN; serum M-CSF ≥ 416.95 vs < 416.95 pg/ml
- MPA with RPGNn = 30
- Outcome
- Serum biomarkers associated with renal disease severity and prognosis (progression to end-stage renal disease (ESRD))
Methodological detailskidney biopsy immunohistochemistry
- Kidney biopsy immunohistochemistry
Main finding
As reported in the abstract
Serum biomarker levels, RPGN vs no RPGN · on admission
- Initial serum M-CSF and TNF-a levels significantly higher in MPA with RPGN than without RPGN
- Serum M-CSF significantly correlated with glomerular and renal tubular damage markers
Further findings
| Outcome | P value |
|---|---|
| 5-year ESRD-progression rate by initial serum M-CSF · 5 yearsM-CSF ≥ 416.95 pg/ml vs M-CSF < 416.95 pg/ml · significantly higher with M-CSF ≥ 416.95 pg/ml | P = 0.0002 |
Kidney biopsy immunohistochemistry
- Enhanced M-CSF expression in glomerular capillary endothelial and tubular epithelial cells in cases with severe glomerular and tubular damage
- High CD163-positive macrophage infiltration into periglomerular and peritubular areas in the sclerotic group
Original publication
M-CSF, inducing CD163 macrophages, is associated with severity and prognosis of glomerulonephritis in microscopic polyangiitis. Arthritis Res Ther. Published 30 December 2025. doi:10.
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