Vasculitis & polymyalgia rheumatica
Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies
Authors' conclusion
MPA is classified into four subtypes with distinct clinical manifestations and prognoses.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) who underwent renal biopsy, among 436 patients with AAV, single centre, 2015 to 2022 (63% female; median age at onset 63 years)median follow-up 26 months
- Participants
- 90 patients
- Exposure
- Four clinical subtypes of MPA
- Outcome
- Clinical subtypes and prognoses (CR, death, renal failure)
Methodological detailssingle-centre, cluster analysis
- Single-centre
- Cluster analysis
Main finding
As reported in the abstract
| Group | Value | Complete remission (CR) | Death | Renal failure |
|---|---|---|---|---|
| Cluster 1 | 39% | 26% | 11% | 19% |
| Cluster 2 | 22% | 55% | 0 | 0 |
| Cluster 3 | 26% | 53% | 9% | 4% |
| Cluster 4 | 13% | 0 | 8% | 75% |
Value
Cluster 139%
Cluster 222%
Cluster 326%
Cluster 413%
Complete remission (CR)
Cluster 126%
Cluster 255%
Cluster 353%
Cluster 40
Death
Cluster 111%
Cluster 20
Cluster 39%
Cluster 48%
Renal failure
Cluster 119%
Cluster 20
Cluster 34%
Cluster 475%
Observational data: associations, not effects.
Original publication
Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies. Arthritis Res Ther. Published 7 December 2023. doi:10.
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