Vasculitis & polymyalgia rheumatica
Impact of gender on baseline presentation and outcome in adult IgA vasculitis
Authors' conclusion
Kidney involvement in IgAV appears to be more severe in males, which is supported by more intensive treatment contrasting with a lower response rate.
Study context
- Population
- Adults with IgA vasculitis (IgAV) in a multicentre retrospective cohort (IGAVAS)259 analysed
- Participants
- 260 adults
- Exposure
- Males vs females with adult IgAV
- Malesn = 164
- Femalesn = 95reference
- Outcome
- Impact of gender on presentation and outcome
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Baseline presentation
- Males
- cutaneous involvement 100% vs 100%; P = 1.0
- Males
- joint involvement 60% vs 63%; P = 0.7
- Males
- gastrointestinal involvement 57% vs 45%; P = 0.093
- Males
- glomerulonephritis 73% vs 64%; P = 0.16
Observational data: associations, not effects.
Further findings
eGFR at baseline
P = 0.015
Proteinuria at baseline
P = 0.01
Methylprednisolone use
P = 0.015
CYC use
P = 0.0025
AZA use
P = 0.038
Refractory disease
P = 0.004
Kidney biopsy histological findings
- No differences in histological findings
Long-term outcomes (mortality, progression to chronic kidney failure)
- Did not differ
Original publication
Impact of gender on baseline presentation and outcome in adult IgA vasculitis. Rheumatology (Oxford). Published 4 December 2023. doi:10.
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