Vasculitis & polymyalgia rheumatica
Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry
Authors' conclusion
BD displays a more severe course among males. This subgroup develops more irreversible damage and presents more frequently ocular and vascular involvement during disease course. On the other hand, female patients are prone to experience articular involvement, headache, CNS and gastrointestinal involvement.
Study context
- Population
- Patients with Behçet's Disease (BD) in the International AIDA Network Registry for BDmale-to-female ratio 1.24/1
- Participants
- 1,024 patients
- Exposure
- Males vs females with BD
- Malesn = 567
- Femalesn = 457reference
- Outcome
- Gender differences in BD, incl. irreversible damage (BODI)
- Follow-up
- Last
Methodological detailsinternational registry (AIDA Network)
- International registry (AIDA Network)
Main finding
As reported in the abstract
BODI
Males
1.92
mean · SD 2.09
Females
1.25
mean · SD 1.87
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cardiovascular riskNo differences between the two groups | P = 0.617 |
Cumulative manifestations more frequent in males
- Uveitis more frequent in males
- P < 0.0001
- Vascular involvement more frequent in males
- P = 0.0076
Cumulative manifestations more frequent in females
- Arthralgia
- P < 0.0001
- Arthritis
- P = 0.00025
- Isolated headache
- P < 0.0001
- Central nervous system (CNS) involvement
- P = 0.040
- Gastrointestinal involvement
- P = 0.00046
Factors associated with major organ involvement
- Male gender, OR
- 2.104 (P=0.001)
- Current treatment with biologic agents, OR
- 2.257 (P=0.0003)
- Origin from endemic countries, OR
- 2.661 (P=0.0009)
- Disease duration, OR
- 1.002 (P=0.024)
Original publication
Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry. Joint Bone Spine. Published 15 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →