Vasculitis & polymyalgia rheumatica
Risk of major organ involvement in Behçet’s patients with mucocutaneous onset: data from the AutoInflammatory Disease Alliance (AIDA) Network Registry
Authors' conclusion
A positive family history and the presence of major oral aphthosis combined with minor oral aphthosis, genital aphthosis or pseudofolliculitis are associated with MOI development in patients with mucocutaneous BD at onset.
Study context
- Population
- Patients with exclusively mucocutaneous manifestations at Behçet's disease (BD) onset, AIDA Network registry
- Participants
- 328 patients
- Exposure
- Clinical features at mucocutaneous BD onset associated with later major organ involvement
- Outcome
- Development of major organ involvement (MOI)
- Follow-up
- Entire
Methodological detailsAIDA Network registry
- AIDA Network registry
Main finding
As reported in the abstract
Development of MOI
- Developed major organ involvement (MOI)
- 82 patients (25%)
- Minor oral aphthosis and no major oral aphthosis (reduced risk), OR
- 0.41 (95% CI 0.22-0.79, P = 0.008)
- Both major and minor oral aphthosis, OR
- 12.76 (95% CI 1.44-113, P = 0.02)
- Major oral aphthosis plus genital aphthosis, OR
- 2.49 (95% CI 1.1-5.6, P = 0.03)
- Major oral aphthosis plus pseudofolliculitis, OR
- 2.9 (95% CI 1.15-7.4, P = 0.02)
- Major oral aphthosis plus both genital aphthosis and pseudofolliculitis, OR
- 3.73 (95% CI 1.22-11.4, P = 0.02)
- Positive family history for BD, OR
- 2.85 (95% CI 1.08-7.58, P = 0.03)
Observational data: associations, not effects.
Original publication
Risk of major organ involvement in Behçet’s patients with mucocutaneous onset: data from the AIDA Network Registry. Rheumatology (Oxford). Published 19 November 2025. doi:10.
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