Vasculitis & polymyalgia rheumatica
Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization
Authors' conclusion
This exploratory multi-omics study identified a set of NET-associated candidate genes showing consistent associations with IgAV.
Study context
- Population
- IgA vasculitis (IgAV) patients and healthy controls; peripheral-blood bulk transcriptomic data
- Comparison
- IgAV patients vs healthy controls
- Outcome
- NET-associated candidate genes related to IgAV
Methodological detailsexploratory, multi-omics, transcriptomics, two-sample Mendelian randomization, cell-type-specific Mendelian randomization (MR), single-cell RNA sequencing (scRNA-seq), 646 NET-associated genes evaluated with gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA); DEGs, GSEA leading-edge genes and transcriptome-wide association study (TWAS)-significant genes intersected
- Exploratory
- Multi-omics
- Transcriptomics
- Two-sample Mendelian randomization
- Cell-type-specific MR
- scRNA-seq
- 646 NET-associated genes evaluated with GSEA and GSVA; DEGs, GSEA leading-edge genes and TWAS-significant genes intersected
Main finding
As reported in the abstract
NET-associated candidate genes
- Five NET-associated candidate genes (AGER, TLR2, CXCR2, TEK, THBD) consistently prioritized across analyses
- 5
Further findings
Single-cell expression
- Genes mainly expressed in myeloid immune subsets, with elevated NETosis-related transcriptional signatures
Intercellular communication
- Enhanced activity of immune-related signalling pathways, incl. MHC-I and MIF, in IgAV samples
Original publication
Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization. Pediatr Rheumatol Online J. Published 5 March 2026. doi:10.
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