Vasculitis & polymyalgia rheumatica
Meta-analysis revealed human leukocyte antigen (HLA) susceptibility markers in ANCA-associated vasculitis and its clinical subtypes
Authors' conclusion
Multiple alleles of HLA-DRB1 and HLA-DPB1 were found to be associated with predisposition to AAV and its subtypes.
Study context
- Population
- Patients with ANCA-associated vasculitis (AAV) and five clinical subtypes; articles published March 2024 or previously
- Comparison
- HLA alleles in AAV and its subtypes
- Outcome
- Association of HLA alleles with AAV and its subtypes (meta-OR, Z test P)
Methodological detailsBonferroni correction, sensitivity analysis, GRADE, Newcastle-Ottawa Scale
- Bonferroni correction
- Sensitivity analysis
- GRADE
- Newcastle-Ottawa Scale
Pooled result
As reported in the abstract
- Significant associations identified
- 30
- Associations withstanding Bonferroni correction
- 17
- rs9277554-C (HLA-DPB1), Meta-OR (P < 0.00001)
- 3.92 (3.27-4.69)
- rs1049072-A (HLA-DQB1), Meta-OR (P < 0.00001)
- 1.39 (1.27-1.52)
- rs9277341-C (HLA-DPA1), Meta-OR (P < 0.00001)
- 0.41 (0.03-0.57)
- HLA-DRB1*09:01 and AAV, Meta-OR (P < 0.00001)
- 1.72 (1.46-2.03)
- HLA-DRB1*09:01 and MPO+AAV, Meta-OR (P < 0.00001)
- 1.65 (1.41-1.93)
- HLA-DRB1*09:01 and microscopic polyangiitis (MPA), Meta-OR (P < 0.00001)
- 1.75 (1.41-2.19)
- HLA-DPB1*01:01 and AAV, Meta-OR (P ≤ 0.0005)
- 0.38 (0.24-0.62)
- HLA-DRB1*11:01 and MPA, Meta-OR (P ≤ 0.0005)
- 2.11 (1.39-3.20)
Further pooled results
Sensitivity analysis
- Additional significant (P ≤ 0.001) alleles HLA-DPB1*04:01 and HLA-DPB1*02:01 predisposing to AAV and to more than one subtype
Original publication
Meta-analysis revealed HLA susceptibility markers in ANCA-associated vasculitis and its clinical subtypes. Rheumatology (Oxford). Published 21 May 2025. doi:10.
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