Vasculitis & polymyalgia rheumatica
Changing incidence and serotype trends in ANCA-associated vasculitis: a 30-year population-based study in Norfolk, UK
Authors' conclusion
This is the longest incidence study of AAV in the world. The incidence of GPA showed a 9-year periodicity. The incidence of MPO AAV rose steadily.
Study context
- Population
- Adults in the county of Norfolk, UK, 1991–2020
- Exposure
- ANCA associated vasculitides (AAV) vs GPA vs microscopic polyangiitis (MPA) vs eosinophilic GPA (EGPA) vs PR3 AAV vs MPO AAV
- Outcome
- Incidence of AAV and its subtypes (GPA, MPA, EGPA, PR3 AAV, MPO AAV), temporal fluctuations and seasonality
Methodological details30-year, EMA classification
- 30-year
- EMA classification
Main finding
As reported in the abstract
Incidence per million person-years · 1991–2020 (PR3/MPO AAV: 2001–2020)
Observational data: associations, not effects.
Further findings
Temporal trends in incidence
- GPA incidence statistical periodicity (years)
- 9
- MPO AAV incidence linear rise 2001–2020, R2
- 0.66
- Temporal fluctuations in EGPA and PR3 AAV incidence not significant
- Patients getting older at diagnosis
- Seasonality not observed
Original publication
Changing incidence and serotype trends in ANCA-associated vasculitis: a 30-year population-based study in Norfolk, UK. Rheumatology (Oxford). Published 26 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →