Vasculitis & polymyalgia rheumatica
Nervous system involvement in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: Single center experience from Latin America
Authors' conclusion
Patients with nervous system involvement showed less severe renal involvement and a lower proportion of 5-year risk of mortality scores; one-year all-cause mortality was similar between groups.
Study context
- Population
- Patients with AAV treated at a university hospital in Colombia, 2005–2023median age 58 years
- Participants
- 48 vs 79
- Comparison
- AAV patients with vs without neurological manifestations
- Casesn = 48
- Controlsn = 79reference
- Outcome
- Frequency and characteristics of nervous system involvement
Methodological detailssingle-centre, survival analysis
- Single-centre
- Survival analysis
Main finding
As reported in the abstract
- Nervous system involvement in undifferentiated AAV
- 100 %
- Nervous system involvement in EGPA
- 75 %
- Nervous system involvement in MPA
- 33.3 %
- Nervous system involvement in GPA
- 25.9 %
- Peripheral neuropathy (most common manifestation)
- 50 %
- Patient-reported symptoms of sensory dysfunction
- 43.7 %
- Cranial neuropathy
- 39.6 %
Observational data: associations, not effects.
Further findings
Creatinine at admission and five-factor score > 2
- Patients with neurological manifestations had a lower median creatinine at admission and a lower proportion with a five-factor score > 2
All-cause mortality · one year
- No differences in one-year all-cause mortality
In-hospital mortality (whole cohort)
%
- In-hospital mortality
- 14
- Diagnosis made during the hospital stay
- 67.7
Original publication
Nervous system involvement in ANCA-associated vasculitis: Single center experience from Latin America. Semin Arthritis Rheum. Published 16 May 2025. doi:10.
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