Vasculitis & polymyalgia rheumatica
Pulmonary manifestations of granulomatosis with polyangiitis and microscopic polyangiitis
Authors' conclusion
Pulmonary manifestations are common in AAV and are associated with permanent damage.
Study context
- Population
- Individuals with ANCA-associated vasculitis (AAV) followed between 2006 and 2023
- Participants
- 1,026 individuals
- Exposure
- Granulomatosis with polyangiitis (GPA) vs microscopic polyangiitis (MPA)
- GPAn = 860
- MPAn = 166
- Outcome
- Pulmonary manifestations at any time in the disease course
Methodological detailsmulticentre, longitudinal
- Multicentre
- Longitudinal
Main finding
As reported in the abstract
Pulmonary manifestations at any time in disease course
- Overall cohort
- 81.3%
Observational data: associations, not effects.
Further findings
Pulmonary manifestations at disease onset
- Overall cohort
- 644 (62.7%)
Pulmonary manifestations during follow-up
- Overall cohort
- 456 (44.4%)
Most common manifestations
- Nodules and cavities, diffuse alveolar hemorrhage, and inflammatory infiltrates were the three most common across the cohort
- Nodules and cavities most frequent in GPA; diffuse alveolar hemorrhage most frequent in MPA
Multiple pulmonary manifestations, among those with pulmonary manifestations
- Multiple pulmonary manifestations
- 51.9%
Pulmonary manifestations in relapse episodes
- Episodes of relapse with pulmonary manifestations
- 41.4%
Safety
Pulmonary damage among those with pulmonary manifestations
- Sustained pulmonary damage
- 17.4%
Original publication
Pulmonary manifestations of granulomatosis with polyangiitis and microscopic polyangiitis. Semin Arthritis Rheum. Published 16 February 2026. doi:10.
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