Vasculitis & polymyalgia rheumatica
Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet’s syndrome
Authors' conclusion
Our study revealed cellular and molecular changes in the aortic tissues of patients with BS
Study context
- Population
- Patients undergoing aortic tissue sampling at Beijing Anzhen Hospital, January 2023–June 2024
- Participants
- 6 patients
- Comparison
- Behçet's syndrome (BS) vs atherosclerosis, aortic tissue
- BSn = 3
- Atherosclerosisn = 3reference
- Outcome
- Aortic tissue cell composition (scRNA-seq)
Methodological detailssingle-cell RNA sequencing, single-centre, Seurat and Harmony in R; GO and KEGG enrichment; CellChat v1.6.1 for intercellular communication
- Single-cell RNA sequencing
- Single-centre
- Seurat and Harmony in R; GO and KEGG enrichment; CellChat v1.6.1 for intercellular communication
Main finding
As reported in the abstract
- Eight major cell types identified, with significant differences in cell proportions between BS and controls
- BS vs controls: increased endothelial cells, fibroblasts and mesenchymal stem cells; decreased smooth muscle cells
- Subgroup analysis: significant differences between BS and controls in cell subpopulation distribution, enriched pathways and cell interactions
Original publication
Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet’s syndrome. Rheumatology (Oxford). Published 15 May 2025. doi:10.
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