Vasculitis & polymyalgia rheumatica
Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis
Authors' conclusion
This study documents a distinct spatial distribution pattern of fibroblast subtypes in GCA-affected arteries.
Study context
- Population
- Temporal artery biopsies and aortic aneurysm tissues from patients with giant cell arteritis (GCA), controls and atherosclerosis
- Participants
- 9 / 15 / 9 / 11
- Comparison
- GCA-affected temporal arteries and aortas vs control temporal arteries and atherosclerosis-related aneurysms
- GCA-TABn = 9
- Controlsn = 15reference
- GCA aortan = 9
- Atherosclerosis aortan = 11reference
- Outcome
- Distribution of fibroblast subtypes in relation to vascular remodelling in GCA
Methodological detailsimmunohistochemistry and immunofluorescence, in vitro siRNA knockdown
- Immunohistochemistry and immunofluorescence
- In vitro siRNA knockdown
Main finding
As reported in the abstract
Distribution of fibroblast subtypes
Proliferative fibroblasts in temporal artery biopsies (TAB) and aorta that were FAP positive
≈80%
Original publication
Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis. Rheumatology (Oxford). Published 14 March 2025. doi:10.
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