Vasculitis & polymyalgia rheumatica
Does plasma exchange have a role in ANCA-associated vasculitis? Viewpoint 1: plasma exchange should not be used indiscriminately
Authors' conclusion
The best data available, through meta-analysis, suggest the effects of plasma exchange in AAV are limited to improving kidney outcomes with a low likelihood of other benefits but also an increase in the risk of serious infections.
Study context
- Population
- Patients with ANCA-associated vasculitis (AAV)
- Comparison
- Plasma exchange vs no plasma exchange in AAV
Methodological detailsnarrative review
- Narrative review
Main finding
As reported in the abstract
- Per meta-analysis, effects of plasma exchange in AAV limited to improving kidney outcomes, with low likelihood of other benefits
- Increase in risk of serious infections with plasma exchange
- Individual RCTs had mixed results
Original publication
Does plasma exchange have a role in ANCA-associated vasculitis? Viewpoint 1: plasma exchange should not be used indiscriminately. Rheumatology (Oxford). Published 12 March 2025. doi:10.
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