Vasculitis & polymyalgia rheumatica
High risk of bloodstream infections, diverse causal pathogens and association with haemodialysis and plasma exchange in ANCA-associated vasculitis
Main finding · BSIsResult — go to the resultHazard ratio 10.5 95% CI 5.58–11.9Authors' conclusion
AAV patients face high BSI risk, diverse microbiology and increased one-year mortality, with CVC-related interventions as solitary risk factors.
Study context
- Population
- Danish nationwide registries: patients with ANCA-associated vasculitis (AAV) diagnosed 2010–2018, followed until first BSI, death or a maximum of 5 yearsmatched cohort
- Participants
- 937 vs 3,476
- Exposure
- Incident AAV vs matched general-population controls
- AAVn = 937
- Controlsn = 3,476reference
- Outcome
- Bloodstream infections (BSIs)
Methodological detailscontrols matched 1:4 by age and sex, Aalen-Johansen cumulative incidence, adjusted Cox regression
- Controls matched 1:4 by age and sex
- Aalen-Johansen cumulative incidence
- Adjusted Cox regression
Main finding
BSIs
Hazard ratio
10.5
95% CI 5.58–11.9
Events by group
AAVvs Controls
HR 10.5 (95% CI 5.58–11.9)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality after first-time BSI · one year
First-time BSI, AAV patients receiving haemodialysis or plasma exchange · one year
- Haemodialysis, HR
- 34.8 (95% CI 3.35-360.8)
- Plasma exchange, HR
- 14.6 (95% CI 3.79-56.6)
Mortality after first-time BSI · one year
- Equally high in AAV patients and controls
Microbial agents
- AAV bloodstream infections (BSIs) attributed to other pathogens (e.g. coagulase-negative staphylococci, K. pneumoniae, P. aeruginosa, fungi)
- 48.6%
- Most common agents (E. coli, S. aureus, enterococci, streptococci) similar between groups
Original publication
High risk of bloodstream infections, diverse causal pathogens and association with haemodialysis and plasma exchange in ANCA-associated vasculitis. Rheumatology (Oxford). Published 19 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →