Vasculitis & polymyalgia rheumatica
Increased risk of cardiovascular disease preceding diagnosis of incident ANCA-associated vasculitis: a Danish nationwide study
Main finding · Any cardiovascular outcomeResult — go to the resultHazard ratio 3.05 95% CI 2.48–3.75Authors' conclusion
AAV disease is associated with an increased risk of cardiovascular disease in the months preceding diagnosis
Study context
- Population
- Danish Nationwide Registries, 1996 to 2021: patients with GPA and MPA (median age 63 years, 53.7% male) and matched controls
- Participants
- 2,371 vs 7,113
- Comparison
- ANCA-associated vasculitis (AAV) vs age- and sex-matched controls without AAV
- AAVn = 2,371
- Controlsn = 7,113reference
- Outcome
- Any cardiovascular outcome and major adverse cardiovascular events (MACE) before index date (AAV diagnosis)
- Follow-up
- 12 months preceding index date
Methodological detailsnationwide registries, matched 1:3 on age and sex, conditional logistic regression
- Nationwide registries
- Matched 1:3 on age and sex
- Conditional logistic regression
Main finding
Any cardiovascular outcome · within 12 months preceding index date
Hazard ratio
3.05
95% CI 2.48–3.75
By group
AAVvs Controls
HR 3.05 (95% CI 2.48–3.75)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | AAV | Controls | HR (95% CI) | |
|---|---|---|---|---|
| MACE · within 12 months preceding index dateAdjusted | 2.4% | 1.3% | 1.98 (1.39–2.82) | |
| Any cardiovascular outcome · 1 month prior to index dateHighest HR | 10.73 (7.05–16.32) | |||
| MACE · 1 month prior to index dateHighest HR | 5.78 (2.67–12.52) | |||
| 0.050.21520Hazard ratio (log scale) |
Individual cardiovascular outcomes
- Significantly higher rate for all outcomes (excluding VA/ICD/CA)
Original publication
Increased risk of cardiovascular disease preceding diagnosis of incident ANCA-associated vasculitis: a Danish nationwide study. Rheumatology (Oxford). Published 22 July 2023. doi:10.
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