Vasculitis & polymyalgia rheumatica
Long-term cardiovascular outcomes and temporal trends in patients diagnosed with ANCA-associated vasculitis: a Danish nationwide registry study
Authors' conclusion
Patients with AAV are at increased risk of heart failure, atrial-/ventricular arrhythmias, venous thrombotic events, ischaemic stroke and myocardial infarction.
Study context
- Population
- Patients with GPA or MPA in Denmark, 1996–2018 (median age 62.9yrs, 52.6% male)median follow-up 9.5yrs
- Participants
- 2,306 vs 6,918
- Exposure
- ANCA-associated vasculitis (AAV) vs age and gender-matched controls
- AAVn = 2,306
- Controlsn = 6,918reference
- Outcome
- Long-term cardiovascular outcomes
Methodological detailsage and gender-matched controls, counterfactual G-estimation of 5-year absolute risks, temporal trends by tertiles of inclusion year
- Age and gender-matched controls
- Counterfactual G-estimation of 5-year absolute risks
- Temporal trends by tertiles of inclusion year
Main finding
As reported in the abstract
Cardiovascular outcomes, AAV vs matched controls · Median follow-up 9.5yrs
AAV vs ControlsHazard ratio (CI)
Ischaemic heart disease
1.86(1.62–2.15)
MI
1.62(1.26–2.09)
Coronary angiogram
1.64(1.37–1.96)
Percutaneous coronary intervention
1.56(1.17–2.07)
Ventricular arrhythmias/ICD-implantations
2.04(1.16–3.57)
Observational data: associations, not effects.
Further findings
5-year absolute risk of all outcomes
- Significantly higher in AAV for all outcomes (excluding ventricular arrhythmia/ICD-implantations)
Temporal trends in AAV: 3-year cardiovascular mortality
- Decreased 3-year risk of cardiovascular mortality over time
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Long-term cardiovascular outcomes and temporal trends in patients diagnosed with ANCA-associated vasculitis: a Danish nationwide registry study. Rheumatology (Oxford). Published 5 July 2022. doi:10.
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