Vasculitis & polymyalgia rheumatica
Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis
Authors' conclusion
Enhanced B cells might contribute to the pathogenesis of TAK, and serum IgG levels could serve as a simple, useful biomarker to assess disease activity and monitor treatment response in TAK.
Study context
- Population
- Newly diagnosed patients with TAK, compared with systemic lupus erythematosus (SLE) patients and healthy controls
- Participants
- 98 / 31 / 60
- Exposure
- Newly diagnosed TAK vs SLE vs healthy controls
- TAKn = 98
- SLEn = 31
- Healthy controls (HCs)n = 60reference
- Outcome
- Peripheral B cells and serum Ig
Methodological detailscomparative with SLE and HCs, 6-month follow-up after immunotherapy, immunohistochemical staining of aortic tissue
- Comparative with SLE and HCs
- 6-month follow-up after immunotherapy
- Immunohistochemical staining of aortic tissue
Main finding
As reported in the abstract
- Proportion of peripheral CD3-CD19+ B cells and serum IgG lower in TAK than in SLE, but higher than in HCs
- CD3-CD19+ B cell counts higher in TAK than in HCs
- Serum IgG and IgG1 higher in active TAK than in non-active TAK
- In TAK, serum IgG positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Kerr score, ITAS2010 and ITAS-A before immunotherapy
- After 6 months of immunotherapy, serum immunoglobulin (Ig) levels significantly decreased; changes in IgG positively correlated with ESR, CRP, Kerr score and ITAS-A
- Immunohistochemistry confirmed CD19+ B cell and IgG infiltration of the aortic wall in TAK
Observational data: associations, not effects.
Original publication
Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis. Clin Exp Rheumatol. Published 2 July 2022. doi:10.
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