Vasculitis & polymyalgia rheumatica
Increased arterial stiffness and accelerated atherosclerosis in Takayasu arteritis
Authors' conclusion
Markedly increased CCA IMT and SWE values appear to be uniquely associated with TAK, suggesting that they could be used as diagnostic tools. Arterial stiffness occurs independently from atherosclerosis and is associated with arterial thickening.
Study context
- Population
- Patients with TAK, patients with systemic lupus erythematosus (SLE) and healthy controls studied with carotid ultrasonography (US) and shear wave elastography (SWE)
- Participants
- 50 / 43 / 57
- Exposure
- TAK vs SLE vs healthy controls
- TAKn = 50
- SLEn = 43
- Healthy controls (HCs)n = 57reference
- Outcome
- Carotid IMT, plaques and SWE (arterial stiffness)
Methodological detailscarotid B mode US and SWE, adjusted for atherosclerotic risk factors, Intra and inter observer reproducibility assessed; good agreement
- Carotid B mode US and SWE
- Adjusted for atherosclerotic risk factors
- Intra and inter observer reproducibility assessed; good agreement
Main finding
As reported in the abstract
- Mean IMT in right and left carotid arteries significantly higher only in TAK vs SLE and HCs
- Carotid artery plaques significantly increased only in TAK
- Mean SWE value significantly increased in both TAK and SLE vs HCs, highest in TAK
- Findings held after adjustment for atherosclerotic risk factors and after excluding those with atherosclerotic plaques
- TAK itself, diastolic blood pressure and IMT independently associated with SWE
Observational data: associations, not effects.
Original publication
Increased arterial stiffness and accelerated atherosclerosis in Takayasu arteritis. Semin Arthritis Rheum. Published 29 March 2023. doi:10.
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