Vasculitis & polymyalgia rheumatica
Dysregulated serum lipid profile and atherosclerosis in untreated female Takayasu arteritis patients: a propensity score-matched analysis
Authors' conclusion
The results of this study indicate that untreated female TA patients exhibit a markedly dysregulated serum lipid profile. Atherosclerosis in early TA was not related to lipids or markers of inflammation.
Study context
- Population
- Untreated female patients with Takayasu arteritis and age- and BMI-matched healthy controls
- Participants
- 50 vs 98
- Exposure
- Untreated female TAK patients vs healthy controls
- Takayasu arteritis (TA)n = 50
- Healthy controlsn = 98reference
- Outcome
- Lipid profiles (TC, TG, HDL-C, LDL-C, ApoA1, ApoB, ApoE, lipoprotein(a)), inflammatory markers (CRP, erythrocyte sedimentation rate (ESR)) and atherosclerotic plaque frequency
Methodological detailspropensity-score matched, healthy controls matched for age and BMI
- Propensity-score matched
- Healthy controls matched for age and BMI
Main finding
As reported in the abstract
Serum lipid profile, TA vs controls
- Triglycerides (TG) and non-HDL-C/high-density lipoprotein cholesterol (HDL-C) ratio significantly higher in TA than controls
- Total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein A1 (ApoA1) significantly lower in TA than controls
Observational data: associations, not effects.
Further findings
- Atherosclerotic plaques in TA
- 14.3%
Correlation of C-reactive protein (CRP) with lipids (Pearson)
- Positive correlation of CRP with ApoB and non-HDL-C/HDL-C ratio
- Negative correlations of CRP with TG, HDL-C and ApoA1
Atherosclerotic plaques in TA
- Plaque presence associated only with age, independent of inflammatory markers and lipoprotein levels (multivariate regression)
Original publication
Dysregulated serum lipid profile and atherosclerosis in untreated female Takayasu arteritis patients: a propensity score-matched analysis. Scand J Rheumatol. Published 6 May 2025. doi:10.
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