Vasculitis & polymyalgia rheumatica
Risk of new-onset polymyalgia rheumatica following COVID-19 vaccination in South Korea: a self-controlled case-series study
Main finding · New-onset PMR after COVID-19 vaccinationResult — go to the resultIncidence rate ratio 0.74 95% CI 0.59–0.94Authors' conclusion
In this nationwide SCCS, there was no association with the increased risk of PMR following COVID-19 vaccination.
Study context
- Population
- Adults aged ≥50 years who received ≥1 dose of COVID-19 vaccine and were subsequently diagnosed with polymyalgia rheumatica (PMR), National Health Insurance Database linked with COVID-19 registry, South Korea, February 2021–August 2023of 44,818,078 vaccine recipients
- Participants
- 376 adults
- Comparison
- Risk window vs control window
- Outcome
- New-onset PMR after COVID-19 vaccination (IRR)
Methodological detailsnationwide, conditional Poisson regression, stratified by dose and vaccine type
- Nationwide
- Conditional Poisson regression
- Stratified by dose and vaccine type
Main finding
New-onset PMR after COVID-19 vaccination · 28 days after each dose
Incidence rate ratio
0.74
95% CI 0.59–0.94
Risk window (28 days after each COVID-19 vaccine dose)vs control window (remainder of 240-day observation period)
IRR 0.74 (95% CI 0.59–0.94)
As reported in the abstract
Further findings
PMR after first dose · 28 days after dose
| IRR (95% CI) | ||
|---|---|---|
| First doseRisk slightly reduced | 0.52 (0.34–0.79) | |
| 0.20.5125Incidence rate ratio (log scale) |
PMR after second dose · 28 days after dose
| IRR (95% CI) | ||
|---|---|---|
| Second dose | 0.83 (0.59–1.16) | |
| 0.512Incidence rate ratio (log scale) |
PMR after third dose · 28 days after dose
| IRR (95% CI) | ||
|---|---|---|
| Third dose | 0.77 (0.48–1.25) | |
| 0.512Incidence rate ratio (log scale) |
Original publication
Risk of new-onset polymyalgia rheumatica following COVID-19 vaccination in South Korea: a self-controlled case-series study. RMD Open. Published 28 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →