Vasculitis & polymyalgia rheumatica
Humoral SARS–CoV‐2 Vaccine Responses in Patients With Giant Cell Arteritis and Polymyalgia Rheumatica: Decay After Primary Vaccination and Effects of the Booster
Authors' conclusion
These results indicate that the decay of humoral immunity after primary vaccination is associated with prednisolone treatment, whereas the subsequent increase after booster vaccination, was not. Patients with low antibody concentrations following primary vaccination remained at an immunogenic disadvantage after a single booster vaccination.
Study context
- Population
- Patients with giant cell arteritis (GCA)/polymyalgia rheumatica (PMR) after primary SARS-CoV-2 vaccination and booster vaccinationpatients n = 24 at 6 months, n = 46 post booster
- Exposure
- GCA/PMR patients vs age-, sex-, and vaccine-matched controls
- Outcome
- Decay of antibody concentrations after primary vaccination and immunogenicity of SARS-CoV-2 booster vaccination
- Follow-up
- 6 months after primary vaccination; 1 month after booster vaccination
Methodological detailsfollow-up study, age-, sex-, and vaccine-matched controls, multiple linear regression
- Follow-up study
- Age-, sex-, and vaccine-matched controls
- Multiple linear regression
Main finding
As reported in the abstract
Antibody concentrations
- Antibody concentrations decreased faster over time in GCA/PMR patients than in controls, associated with prednisolone treatment during primary vaccination
- Post-booster antibody concentrations comparable between patients and controls
Observational data: associations, not effects.
Further findings
Predictors of post-booster antibody concentrations
- Antibody concentrations post primary vaccination, but not treatment during booster vaccination, were predictive
Original publication
Humoral SARS–CoV‐2 Vaccine Responses in Patients With Giant Cell Arteritis and Polymyalgia Rheumatica: Decay After Primary Vaccination and Effects of the Booster. Arthritis Care Res (Hoboken). Published 4 August 2023. doi:10.
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