Vasculitis & polymyalgia rheumatica
Establishment and validation of a novel risk stratification scale in adult IgA vasculitis nephritis: a cohort study based on a systematic review and meta-analysis
Authors' conclusion
In this study, we established a simple and practical tool to identify adult IgAVN patients at high risk of unfavourable outcomes.
Study context
- Population
- Adult patients with IgA vasculitis nephritis (IgAVN); external validation in Chinese patients
- Participants
- 1,814 patients10 cohorts
- Outcome
- Performance of the risk stratification scale for unfavourable outcomes
Methodological detailssystematic review and meta-analysis derivation cohort, derivation from meta-analysis of existing cohorts
- Systematic review and meta-analysis derivation cohort
- Derivation from meta-analysis of existing cohorts
Performance
As reported in the abstract
Unfavourable outcomes: scale performance in external validation cohort (n = 133)
AUC of the scoring scale
0.88
95%CI 0.78–0.99
Sensitivity at cut-off value of 3
0.79
95%CI 0.49–0.95
Specificity at cut-off value of 3
0.89
95%CI 0.82–0.94
Original publication
Establishment and validation of a novel risk stratification scale in adult IgA vasculitis nephritis: a cohort study based on a systematic review and meta-analysis. Clin Exp Rheumatol. Published 25 April 2025. doi:10.
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