Vasculitis & polymyalgia rheumatica
Exhausted natural killer cells in adult IgA vasculitis
Authors' conclusion
Patients with IgAVN exhibited impaired cytotoxic and immunomodulatory functions of NK cells, along with a marked absence of interferon signaling in PBMCs.
Study context
- Population
- Adult patients with IgA vasculitis (IgAV) and healthy controls
- Comparison
- Adult IgAV patients vs healthy controls
- Outcome
- NK cell function and leukocyte gene expression
Methodological detailsRNA sequencing, flow cytometry, Luminex xMAP, qPCR
- RNA sequencing
- Flow cytometry
- Luminex xMAP
- qPCR
Main finding
As reported in the abstract
- % CD107a+ natural killer (NK) cells significantly increased after stimulation in healthy controls (HC)
- p = 9.7 × 10- 3
- % CD107a+ NK cells significantly increased after stimulation in skin-limited IgAV (sl-IgAV)
- p = 2.21 × 10- 2
- Significant reduction in intracellular perforin after phytohemagglutinin (PHA)/IL-2 stimulation in HC
- p = 2.53 × 10- 2
- Interferon (IFN)-ϒ significantly decreased in NK cell culture supernatants from igA vasculitis nephritis (IgAVN)
- p = 2.64 × 10- 2
- MIP-1β significantly decreased in NK cell culture supernatants from IgAVN
- p = 2.65 × 10- 2
Original publication
Exhausted natural killer cells in adult IgA vasculitis. Arthritis Res Ther. Published 23 April 2025. doi:10.
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