Vasculitis & polymyalgia rheumatica
Myocardial infarction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis: a population-based cohort study
Main finding · First MIResult — go to the resultIncidence rate ratio 1.9 95% CI 1.3–2.8Authors' conclusion
The MI IR is greater in individuals diagnosed with AAV compared with background population, especially those with more severe disease, and highest in the 3 months following diagnosis. Age at diagnosis is the single independent predictor of MI in AAV in this study.
Study context
- Population
- Patients diagnosed with AAV 1997–2016 in Skåne, Sweden325 AAV patients included
- Participants
- 282 vs 2,763
- Exposure
- AAV vs age- and sex-matched reference subjects from the background population
- AAVn = 282
- Referencen = 2,763reference
- Outcome
- IR of first MI after AAV diagnosis and IRR of MI in AAV vs background population
Methodological detailsage-matched and sex-matched reference subjects (10 per patient), Cox regression
- Age-matched and sex-matched reference subjects (10 per patient)
- Cox regression
Main finding
First MI
Incidence rate ratio
1.9
95% CI 1.3–2.8
Events by group
AAV
11%
37
AAVvs Reference
IRR 1.9 (95% CI 1.3–2.8)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| MI in MPO-ANCA+ disease (subgroup) | 2.5 (1.5–4.3) | |
| MI in high disease activity at diagnosis (subgroup) | 2.1 (1.3–3.3) | |
| 0.20.5125Incidence rate ratio (log scale) |
- Myocardial infarction (MI) incidence rate (IR) in the 3 months following AAV diagnosis
- 11.8/100 person-years · 95% CI 6.2–22.7
Predictors of MI (Cox regression)
- Age at AAV diagnosis independently predicted MI
Original publication
Myocardial infarction in ANCA-associated vasculitis: a population-based cohort study. RMD Open. Published 17 April 2025. doi:10.
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