Vasculitis & polymyalgia rheumatica
Myocardial infarction in a population-based cohort of patients with biopsy-confirmed giant cell arteritis in southern Sweden
Main finding · Incident MIResult — go to the resultIncidence rate ratio 1.29 95% CI 1.05–1.59Authors' conclusion
The highest incidence of MI occurs within the 30 days following diagnosis of GCA. Individuals with GCA have a moderately increased risk of MI compared with a reference population. Incident MI has a major impact on mortality in GCA.
Study context
- Population
- Individuals with biopsy-confirmed giant cell arteritis (GCA) diagnosed 1998–2016 in Skåne, Sweden
- Participants
- 1,134 individuals7,958 person-years
- Exposure
- Biopsy-confirmed GCA vs matched reference subjects from the general population
- GCAn = 1,134
- Outcome
- Incidence rate of MI
Methodological detailsmatched reference cohort (10 per GCA case, for age, sex and area of residence), biopsy-confirmed GCA
- Matched reference cohort (10 per GCA case, for age, sex and area of residence)
- Biopsy-confirmed GCA
Main finding
Incident MI
Incidence rate ratio
1.29
95% CI 1.05–1.59
GCAvs Reference population
IRR 1.29 (95% CI 1.05–1.59)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality, GCA withvs without incident MI | 2.8 (2.2–3.6) | |
| 0.20.5125Hazard ratio (log scale) |
Timing of myocardial infarction (MI) incidence
- Incidence rate (IR) highest in the 30 days following GCA diagnosis and declined thereafter
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Myocardial infarction in a population-based cohort of patients with biopsy-confirmed giant cell arteritis in southern Sweden. RMD Open. Published 10 April 2024. doi:10.
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