Vasculitis & polymyalgia rheumatica
High risk of stroke in ANCA-associated vasculitis—a population-based study
Main finding · Stroke incidence rate (per 1000 person-years)Result — go to the resultStandardized incidence ratio 1.85 95% CI 1.27–2.59Authors' conclusion
The incidence rate of stroke in AAV is higher than in the general population. High platelet count at AAV diagnosis was associated with an increased risk of stroke.
Study context
- Population
- Patients diagnosed with ANCA-associated vasculitis (AAV) 1997–2016 in a defined geographic area of Sweden (Skåne)
- Participants
- 325 patients2,206 person-years
- Exposure
- AAV vs Swedish general population
- AAVn = 325
- Outcome
- Incidence rate of stroke per 1000 person-years
Methodological detailsStandardized incidence ratio (SIR) vs Swedish general population, Cox regression
- SIR vs Swedish general population
- Cox regression
Main finding
Stroke incidence rate (per 1000 person-years)
Standardized incidence ratio
1.85
95% CI 1.27–2.59
By group
AAV
11.3
95% CI 6.9–15.8 · /1000 person-years
AAVvs General population
SIR 1.85 (95% CI 1.27–2.59)
As reported in the abstract
- Stroke during 2206 person-years of follow-up
- 25 (8%)
Observational data: associations, not effects.
Further findings
| Outcome | SIR (95% CI) | |
|---|---|---|
| Stroke in those <65 years (subgroup) | 3.19 (1.53–5.88) | |
| 0.20.5125Standardized incidence ratio (log scale) |
Predictor of stroke: higher platelet count at AAV diagnosis
| HR (95% CI) | ||
|---|---|---|
| Higher platelet countIndependent predictor | 1.14 (1.00–1.29) | |
| 0.512Hazard ratio (log scale) |
Survival and other outcomes, AAV with vs without stroke
- No differences in survival or other outcome measures between AAV patients with and without stroke
Original publication
High risk of stroke in ANCA-associated vasculitis—a population-based study. Rheumatology (Oxford). Published 28 November 2022. doi:10.
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