Vasculitis & polymyalgia rheumatica
Factors associated with thrombosis in Behçet Syndrome: A systematic review and meta-analysis
Pooled result · Thrombosis risk with Factor V Leiden mutation among patients with BSResult — go to the resultOdds ratio 2.58 95% CI 1.76–3.78Authors' conclusion
Prothrombotic factors do not seem to be the main driver of thrombosis in BS, but may pose an additional risk when present.
Study context
- Population
- Studies assessing factors associated with thrombosis in patients with Behçet syndrome (BS) (PubMed and EMBASE)101 studies
- Comparison
- BS patients with thrombosis vs BS patients without thrombosis; BS patients with thrombosis vs non-BS patients with thrombosis
- Outcome
- Factors associated with thrombosis in BS
Pooled result
As reported in the abstract
Thrombosis risk with Factor V Leiden mutation among patients with BS
Odds ratio
2.58
95% CI 1.76–3.78
BS with thrombosisvs BS without thrombosis
OR 2.58 (95% CI 1.76–3.78)
Further pooled results
BS with thrombosis vs non-BS with thrombosis (6 studies, 14 factors)
- JAK-2 mutation, activated protein C resistance, tissue plasminogen activator (tPA) levels and tPA activity significantly higher among non-BS patients with thrombosis
Original publication
Factors associated with thrombosis in Behçet Syndrome: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 16 April 2025. doi:10.
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