Vasculitis & polymyalgia rheumatica
Thyroid disease in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis: a clinical and epidemiological study
Authors' conclusion
TD is a common comorbidity in AAV, affecting nearly one in five.
Study context
- Population
- Patients with AAV in two cohorts (southern Sweden and Cambridge, UK)
- Participants
- 644 patients2 cohorts
- Exposure
- AAV with thyroid disease (TD) vs AAV without TD
- Southern Swedenn = 325
- Cambridgen = 319
- Outcome
- Prevalence and incidence of TD in AAV, and predictors of de novo TD
Methodological detailspopulation-based cohort (southern Sweden), specialised vasculitis centre cohort (Cambridge, UK), Cox regression
- Population-based cohort (southern Sweden)
- Specialised vasculitis centre cohort (Cambridge, UK)
- Cox regression
Main finding
As reported in the abstract
TD in AAV
TD at AAV diagnosis (77 females; 59 MPO-ANCA+, 34 PR3-ANCA+)
100
15.5%
De novo TD during 4522 person-years (PY) of follow-up
29
Incidence rate of TD
641/100 000 PY
Prevalence of TD in southern Sweden
18%
Observational data: associations, not effects.
Further findings
Predictors of de novo TD
- No analysed factor predicted de novo TD in AAV
Clinical features and outcomes with pre-existing TD
- Patients with TD tended to have lower CRP, lower haemoglobin and fewer constitutional symptoms
- Survival and renal survival greater with pre-existing TD
Original publication
Thyroid disease in ANCA-associated vasculitis: a clinical and epidemiological study. RMD Open. Published 30 April 2024. doi:10.
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