Vasculitis & polymyalgia rheumatica
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Authors' conclusion
Skin transcriptomic data revealed deregulations in lipid metabolism and acute inflammatory response, reflected also in serum analyte measurements.
Study context
- Population
- Adults with Immunoglobulin A vasculitis (IgAV) and healthy controls (HC); skin biopsies (6 IgAV, 3 HC) and sera (59 IgAV, 22 HC)skin: 6 IgAV, 3 HC
- Comparison
- Adult IgAV vs healthy controls
- Outcome
- Skin transcriptomic signature and serum biomarkers predicting IgAV and its organ involvement
Methodological detailsskin RNA sequencing, serum biomarker measurement, machine learning prediction models
- Skin RNA sequencing
- Serum biomarker measurement
- Machine learning prediction models
Main finding
As reported in the abstract
Differentially expressed genes (DEGs) in all IgAV vs HC
49
DEGs vs HC: renal involvement vs skin only
507 vs. 46
Serum analytes significantly higher in IgAV vs HC (p-adj < 0.05): osteopontin, lipopolysaccharide binding protein (LBP), ANGPTL4, IL-15, FABP4, CCL19, kallikrein-5, CCL3, leptin, IL-18, MMP1
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Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers. Arthritis Res Ther. Published 12 April 2024. doi:10.
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