Vasculitis & polymyalgia rheumatica
Clinical features and gastrointestinal bleeding risk factors in IgA vasculitis patients: a retrospective study in a large volume centre
Authors' conclusion
Summer onset, elevated NAR, and decreased MPV help identify IgAV patients at high risk of GI bleeding.
Study context
- Population
- Patients with Immunoglobulin A Vasculitis (IgAV), Affiliated Hospital of Southwest Medical University, 2019–2024
- Participants
- 968 patients
- Exposure
- IgAV with gastrointestinal (GI) bleeding vs without GI bleeding
- GI bleedingn = 484
- Non-bleedingn = 484reference
- Outcome
- Clinical risk factors and prediction model for IgAV-related GI bleeding
Methodological detailssingle-centre, multivariate logistic regression, ROC curve validation
- Single-centre
- Multivariate logistic regression
- ROC curve validation
Main finding
As reported in the abstract
Predictors of GI bleeding
Odds ratio (95% CI)P value
Summer onsetvs Other seasons13.8% absolute risk increase (p<0.001)
1.67(1.15–2.45)
P = 0.007NAR (strongest biochemical predictor)AUC=0.723
1.79(1.33–2.47)
High systemic immune-inflammation index
2.91(1.67–5.08)
MPV (protective)
0.78(0.68–0.90)
- Combined model (seasonality, neutrophil-to-albumin ratio (NAR), mean platelet volume (MPV)) AUC
- 0.742 (95% CI 0.711-0.772)
Observational data: associations, not effects.
Original publication
Clinical features and gastrointestinal bleeding risk factors in IgA vasculitis patients: a retrospective study in a large volume centre. Clin Exp Rheumatol. Published 25 August 2025. doi:10.
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