Vasculitis & polymyalgia rheumatica
Effect of Nonimmune Factors on Renal Prognosis in Adult IgA Vasculitis With Nephritis: A Long-Term Retrospective Cohort Study
Authors' conclusion
The present adult IgAV-N cohort revealed a relatively young onset age, and lower incidence of nephrotic syndrome and ESKD. Moreover, nonimmune factors such as history of HTN and renal chronic histological lesions in biopsy played a crucial role in prognosis of IgAV-N.
Study context
- Population
- Adults with biopsy-proven immunoglobulin A vasculitis (IgAV) nephritis (IgAV nephritis (IgAV-N)), single Chinese centre94 with follow-up data
- Participants
- 106 adults
- Outcome
- Long-term prognostic factors for poor outcome:
- Death
- ESKD
- >30% eGFR reduction
- Follow-up
- Median 102 months
Methodological detailssingle-centre, multivariate Cox proportional analyses
- Single-centre
- Multivariate Cox proportional analyses
Main finding
As reported in the abstract
Independent prognostic factors for poor outcome (multivariate Cox)
- Hypertension (HTN) history was an independent prognostic factor for poor outcome
- >10% global sclerosis at presentation was an independent prognostic factor for poor outcome
Observational data: associations, not effects.
Further findings
Outcomes during follow-up · median follow-up 102 months
- Died
- 7.4%
- Progressed to endstage kidney disease (ESKD)
- 4.3%
- >30% estimated glomerular filtration rate (eGFR) reduction from baseline
- 6.4%
Baseline characteristics · at biopsy
- Age, median (IQR 24-53), years
- 38
- Male
- 52.8%
- Blood pressure, median, mmHg
- 126/80
- Hypertensive at baseline
- 25.5%
- Initial proteinuria, median (IQR 0.7-2.2), g/day
- 1.4
- eGFR, median (IQR 84-121), mL/min/1.73 m²
- 103
- Onset to biopsy, median (IQR 3-40), weeks
- 8
- Global sclerosis, median (IQR 0.0-13.8)
- 5.9%
- Interstitial fibrosis and tubular atrophy
- 45.3%
Original publication
Effect of Nonimmune Factors on Renal Prognosis in Adult IgA Vasculitis With Nephritis: A Long-Term Retrospective Cohort Study. J Rheumatol. Published 1 May 2023. doi:10.
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