Vasculitis & polymyalgia rheumatica
Earliest total vascular damage index scores independently predict all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis
Main finding · All-cause mortalityResult — go to the resultRelative risk 6.090Authors' conclusion
This study was the first to demonstrate that the earliest total VDI score could predict all-cause mortality during follow-up in AAV patients.
Study context
- Population
- AAV patients first diagnosed at one hospital, 2001–2022 (median age 60.0 years; 35.5% men)39 (13.3%) died
- Exposure
- Earliest total Vasculitis Damage Index (VDI) score ≥3.0 vs <3.0
- Outcome
- All-cause mortality during follow-up
Methodological detailssingle-centre, ROC-derived cut-off, multivariable Cox hazards model
- Single-centre
- ROC-derived cut-off
- Multivariable Cox hazards model
Main finding
All-cause mortality
Relative risk
6.090
As reported in the abstract
- Optimal cut-off of earliest total VDI score 3.0: sensitivity
- 64.1%
- Optimal cut-off of earliest total VDI score 3.0: specificity
- 75.2%
Observational data: associations, not effects.
Further findings
Cumulative patients' survival
- Significantly lower in VDI ≥3.0 than in those without
Earliest VDI score and damaged system
- Median earliest VDI score
- 3.0
- Most common damaged system: pulmonary
- 55.3%
Original publication
Earliest total vascular damage index scores independently predict all-cause mortality in patients with ANCA-associated vasculitis. Clin Exp Rheumatol. Published 27 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →