Vasculitis & polymyalgia rheumatica
Performance of clinical and histological prognostic scores for kidney survival in ANCA-associated vasculitis
Authors' conclusion
The novel AKRiS enhances the prediction of kidney failure in AAV with kidney involvement.
Study context
- Population
- Antibodies-associated vasculitis (AAV) patients with biopsy-diagnosed kidney involvement followed for ≥12 months37 progressed to kidney failure
- Participants
- 101 patients
- Exposure
- Histological classifications and prognostic scores for kidney survival
- Outcome
- Time to kidney failure
Methodological detailsprognostic score comparison, Harrell's C statistic and Akaike's Information Criteria
- Prognostic score comparison
- Harrell's C statistic and Akaike's Information Criteria
Main finding
As reported in the abstract
Discrimination for kidney failure (Harrell's C statistic) · median follow-up 75 months (IQR 39-123)
| Group | Harrell's C |
|---|---|
| EUVAS/Berden classification | 0.702 (0.620-0.784) |
| Mayo Clinic Chronicity Score | 0.606 (0.473-0.738) |
| Percentage of ANCA Crescentic Score (PACS) | 0.801 (0.736-0.867) |
| ANCA renal risk score (ARRS) | 0.782 (0.706-0.858) |
| ANCA kidney risk score (AKRiS) | 0.817 (0.749-0.885) |
Harrell's C
EUVAS/Berden classification0.702 (0.620-0.784)
Mayo Clinic Chronicity Score0.606 (0.473-0.738)
Percentage of ANCA Crescentic Score (PACS)0.801 (0.736-0.867)
ANCA renal risk score (ARRS)0.782 (0.706-0.858)
ANCA kidney risk score (AKRiS)0.817 (0.749-0.885)
Observational data: associations, not effects.
Further findings
AKRiS performance over follow-up
- AKRiS performance decreased with longer follow-up intervals
- Adding peak post-therapy eGFR improved AKRiS performance at all follow-up intervals
Kidney relapses precipitating kidney failure in cases progressing after the first year · after the first year of follow-up
- Kidney relapses precipitated kidney failure
- 71%
Original publication
Performance of clinical and histological prognostic scores for kidney survival in ANCA-associated vasculitis. Rheumatology (Oxford). Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →